Nuclear receptor subfamily five group A member two (NR5A2) has a critical role in the occurrence and progression of cutaneous squamous cell carcinoma (cSCC), and it may be played via the Wnt/β‐catenin, at the same time, knockdown of NR5A2 expression mediates the effect of cisplatin in cSCC. This evidence concerns the gene NR5A2 and skin squamous cell carcinoma.