By contrast, mice with chronic IFN-α production in the brain driven by GFAP-expressing astrocytes (termed “GIFN” mice) closely mirror the neuropathological and clinical features observed not only in the brain of patients with AGS, but also of patients with other cerebral interferonopathies (26, 27). The gene discussed is IFNA1; the disease is Aicardi-Goutieres syndrome.