The Runx family of transcription factors (Runx1, Runx2, and Runx3), which heterodimerize with mammalian core binding factor β (CBFB) to form the hematopoiesis regulator core binding factor (CBF), plays central roles in acute myeloid leukemias (AMLs) initiated by the RUNX1::RUNX1T1 and CBFB::MYH11 oncofusions (3). Here, RUNX1 is linked to acute myeloid leukemia.