Paracetamol has been proposed to lower body temperature and thereby protect from severe outcome of other stroke types being acute ischemic and hemorrhagic stroke, but this is not yet supported by evidence from a large clinical trial, and no evidence for a role in ASAH has been shown.29 Further studies to identify the causal genes underlying the observed pleiotropy between paracetamol and IA may help understand the underlying pathogenic processes. This evidence concerns the gene ASAH1 and stroke disorder.