DNMT3A and type 2 diabetes mellitus: In total, CHIP with VAF ≥0.02 was identified in 12 584 individuals, and the most commonly mutated CHIP driver genes were DNMT3A, TET2, and additional sex combs-like 1 (ASXL1; Figure S1).1–3,5,15,22–24 In Cox proportion hazard models adjusted for age, age2, sex, smoking history, genetic ancestry, body mass index, type 2 diabetes, hypertension, CAD, and LDL,15 the presence of CHIP significantly associated with incident AF (hazard ratio [HR], 1.113 [95% CI, 1.044–1.187]; P=0.001; Figure 1A and 1B).