STUB1 and atrial fibrillation: Individuals with expanded CHIP clones (VAF ≥0.1) have a greater risk of developing malignant and nonmalignant manifestations, including CVD.1–3,25 In this analysis, individuals with expanded CHIP clones had a higher incidence of AF compared with individuals without CHIP (HR, 1.132 [95% CI, 1.049–1.222]; P=0.00142; Figure 1A and 1B).