We found an association between CHIP and AF in the UK Biobank population, consistent with previous findings, and demonstrated that the risk of AF is dependent on the CHIP genotype.55 Individuals with mutations of TET2 had augmented risk of developing AF relative to those with DNMT3A or CHIP mutations with smaller VAF size clones, recapitulated in our murine models. The gene discussed is DNMT3A; the disease is atrial fibrillation.