TET2 and hydrops fetalis: Mutant clone size, as assessed by VAF, is associated with greater risk of atherosclerotic disease, HF, and other inflammatory disorders.3,5,22,26,33–35 To assess the effect of hematopoietic-specific inactivation of Tet2 chimerism and clonal expansion, we generated chimeric mice by transplanting bone marrow consisting of 10% WT (CD45.2) and 90% WT (CD45.1) or 10% hematopoietic-specific inactivation of Tet2 (CD45.2) and 90% WT (CD45.1) into lethally irradiated Ldlr−/− (CD45.1) recipients and fed WD for 6 to 9 weeks (Figure S5A).