Although TET2 mutations with a VAF ≥0.1 showed the strongest association with incident AF compared with those without CHIP (HR, 1.27 [95% CI, 1.077–1.498]; P=0.0044), DNMT3A or ASXL1 mutations at the same VAF did not associate significantly (HR, 1.02 [95% CI, 0.914–1.139]; P=0.718; HR, 1.176 [95% CI, 0.972–1.422]; P=0.096, respectively; Figure 1C). This evidence concerns the gene TET2 and atrial fibrillation.