NLRP3 and atrial fibrillation: Increased atrial Nlrp3 inflammasome activation has been shown to promote electrical remodeling and increase AF susceptibility in mice.9,30 To examine the necessity of the Nlrp3 inflammasome in atrial arrhythmogenesis in our model, we generated models of Nlrp3 inactivation through genetic ablation and pharmacological inhibition.