MAPT and Alzheimer disease: Anatomically, the insoluble amyloid-beta peptides (Aβ) in extracellular neuritic plaques and the hyperphosphorylated microtubule-associated Tau protein in intraneuronal neurofibrillary tangles (NFT) are the two neuropathological hallmarks in AD (Busche and Hyman, 2020; Yang X. et al., 2023).