According to NHANES III study, Vit-D deficiency was associated with CVD.38 Furthermore, in recent decades, a growing literature has revealed Vit-D suppresses the inflammatory response and NF-κB pathway, thereby attenuating the progression of CAD.39,40 In the present study, Vti-D levels of CAD patients were significantly lower than controls (P < 0.05). Here, NFKB1 is linked to coronary artery disorder.