Interaction between MMP-9/TIMP-1 and cytokines is the critical feature of CAD progression, severity and predicting the formation of stable plaque or rupture in susceptible patients.30,31 It was found that There was a negative association between IL-6 levels and PBMC TIMP-1 gene expression (P = 0.003). The gene discussed is MMP9; the disease is coronary artery disorder.