IL-17A, a proinflammatory cytokine, increases CXC ligand (CXCL)8 production in epithelial cells and activates fibroblasts to recruit neutrophils (90), while neutrophils generate reactive oxygen species (ROS) that irritate and destroy follicular integrity, causing inflammatory progression of acne lesions, which are then classified as pustules (91, 92). The gene discussed is CXCL8; the disease is acne.