CD68 and neoplasm: The reason is possibly due to a unique pancreatic tumor microenvironment (TME), which is characterized by abundant stromal content enriched with FAP+ cancer-associated fibroblasts, poor vasculature, and immunosuppressive cells such as regulatory T cells, CD68+ M2-like tumor-associated macrophages (TAMs), and myeloid-derived suppressor cells (MDSCs) (20, 21).