VISTA is overexpressed in several malignancies, like breast cancer (52), hepatocellular carcinoma (HCC) (53), gastric cancer (54), colorectal cancer (55), gliomas (56), brain metastasis of lung adenocarcinoma (57), non-small cell lung cancer (NSCLC) (58), oral squamous cell carcinoma (59), cervical cancer (60), ovarian cancer (61), endometrial cancer (32), clear cell renal cell carcinoma (62), and gestational trophoblastic neoplasia (63). The gene discussed is VSIR; the disease is oral cavity squamous cell carcinoma.