IL6 and autoimmune disease: (38) found that pro-inflammatory cytokines (such as interleukin-1β, IL-6) and oxidative stress reduced the uptake of tyrosine in human fibroblasts, and it is speculated that the long-term chronic inflammation and stress in autoimmune diseases may cause abnormal transport of tyrosine, leading to dopamine and norepinephrine neurotransmission disorders in the brain.