The two most down-regulated proteins, CD63 and CD81, which is one of the HCV entry receptors, were independently confirmed upon electroporation of Huh7.5 hepatoma cells with a viral genome RNA encoding for a fluorescently labeled NS5A fusion protein (Jc1_NS5A-eGFP) (Figure 1B). This evidence concerns the gene CD63 and hepatocellular carcinoma.