Furthermore, NF-κB is activated via HCV Core inducing proliferation of hepatoma cells and possibly tumor formation (You et al., 1999; Yoshida et al., 2001; Nguyen et al., 2006; Sato et al., 2006; Selimovic et al., 2012; Simonin et al., 2013). This evidence concerns the gene NFKB1 and neoplasm.