According to the CSCO guidelines, neoadjuvant chemotherapy is recommended for the following patients: (1) large masses (> 5cm); (2) axillary lymph node metastasis; (3) Positive HER-2; (4) Triple negative; (5) There is a desire to preserve the breast, but the ratio of tumor size to breast volume is large and difficult to preserve the breast. Here, ERBB2 is linked to neoplasm.