Bacteriological and inflammatory theories have suggested that after entering the bloodstream, the bacterial periodontopathogens involved in the association between these two diseases cause bacteremia and inflammation at a distance from the oral cavity by bacterial translocation.5 These bacteria can invade, penetrate, and persist in vascular endothelial cells.13-15 Bacteremia causes an inflammatory syndrome resulting in an increase in pro-inflammatory mediators, including interleukins (IL-1 and IL-6) and tumor necrosis factor-α (TNF-α). The gene discussed is TNF; the disease is bacterial infectious disease with sepsis.