ADIPOR2 and hydrops fetalis: Among the molecular mechanism underlying HF progression, epigenetic regulation mediated by miRNAs is emerging.31, 32 As to the impact of hsa-miRs on the ADPN system in HF, it was observed that hsa-miR-150, selected by bioinformatics approach, was 1.7-fold higher in end-stage HF adult patients compared to control and that the levels of hsa-miR-150 were negatively related to AdipoR2 transcript levels.23