Several evidences in animal and human HF models suggest that the ADPN system is involved in cardiac remodeling by multiple beneficial effects, including anti-hypertrophic, anti-fibrotic, and anti-apoptotic actions.15, 16, 25, 27, 28 Paradoxically, circulating levels of ADPN increase in HF patients and are related to the worst outcome. Here, ADIPOQ is linked to hydrops fetalis.