A 77-year-old male with no family history of cancer suffered from upper abdominal pain for more than half months in August 2020 and was diagnosed with stage IV (cT3N3M1c) lung squamous cell carcinoma (LUSC) harboring both a rare <i>EGFR</i> p.G719C mutation and high expression of <i>PD-L1</i> (tumor proportion score [TPS] = 90%). The gene discussed is CD274; the disease is neoplasm.