A retrospective study conducted in Sweden showed that, compared with an age-matched, PCa-free comparison cohort, men with PCa on ADT had an elevated risk of CVD (hazard ratio [HR] 1.21 and 95% confidence interval [CI] 1.18–1.25 for LHRH agonists; HR 1.16 and 95% CI 1.08–1.25 for orchiectomy). Here, GNRH1 is linked to posterior cortical atrophy.