The severity of varicose veins, co-infection, ascites, portal vein thrombosis or tumor thrombus, Child Pugh grade C in the failed endoscopic treatment group were higher than those in the successful hemostasis group, and the activities of albumin and prothrombin were lower than those in the successful hemostasis group P<0.05, the difference was statistically significant. The gene discussed is F2; the disease is Portal vein thrombosis.