Levels of IL-2, IL-5, IL-11, IL-17, CTLA4, TNF-β were higher in RA patients than in the control group (P<0.05), meanwhile, the levels of IL-8, PD-L2, TNF-β and B7-2 were low in RA patients (P>0.05). The gene discussed is PDCD1LG2; the disease is rheumatoid arthritis.