Circ-TLK1 and LncRNA HOSD-AS1 increased SOX4 expression by sponging miR-138–5p and miR-130a-3p, respectively, affecting EMT regulation and promoting aggressive HCC cell behavior (Wang et al., 2017; Lu Y. et al., 2022b). The gene discussed is SOX4; the disease is hepatocellular carcinoma.