PDK2 and hepatocellular carcinoma: Additionally, circ0091579 acted as an oncogenic factor in HCC development and progression by regulating ceRNA networks, including miR-136–5p/TRIM27 (Mao et al., 2022), miR-1287/PDK2 (Shu et al., 2021), miR-1225–5p/PLCB1 (Zhang et al., 2022a).