Furthermore, circ0000437 and circ0071662, aberrantly expressed in both HCC tissues and serum, are linked to tumor-node-metastasis (TNM) grade, differentiation degree, tumor size, and BCLC stage through their ceRNA networks circ0000437/miR-626/CDKN1B (Li and Liu, 2022) and circ0071662/miR-146b-3p/HPGD/NF2 (Abulizi et al., 2019) underlining their substantial clinical diagnostic relevance (Chen et al., 2022a; Wang et al., 2023). The gene discussed is HPGD; the disease is neoplasm.