Researchers developed a chimeric ATP-releasing guanine oxidation probe (ARGO) that merges 8-oxodGTP and ATP to assess MTH1 enzyme activity in various cancers, including colorectal cancer (CRC), non-small cell lung cancer (NSCLC), and pancreatic ductal adenocarcinoma (PDAC), as well as in corresponding normal tissues. The gene discussed is NUDT1; the disease is colorectal cancer.