Studies have shown that the inflammatory state contributes to angiogenesis, cancer cell proliferation, tumour metastasis, and overall disease progression.7,8 Serum levels of albumin and C-reactive protein (CRP) serve as established markers for systemic inflammation and nutritional status, respectively.9,10 The modified Glasgow Prognostic Score (mGPS) that considers both levels of albumin and CRP, currently serves as a prognostic indicator for multiple cancers, including LC.11-14 Patients with both hypoalbuminemia (<35 mg/L) and increased CRP (>10 mg/L) levels receive a score of Two. This evidence concerns the gene CRP and laryngotracheoesophageal cleft.