However, in contrast some studies on patients with acromegaly have reported no effect of this polymorphism on adult height.13,24 Furthermore, a review-based study analyzed the effect of the GHRd3 polymorphism on weight, height, IGF-1 levels, and cardiovascular risk factors from 31 published articles in different populations and concluded a lack of association between the GHRd3 polymorphism and any of these parameters.25 This evidence concerns the gene IGF1 and acromegaly.