In our study, we found that DD genotypes of the ACE gene were strongly associated with HTN as compared to healthy individuals (p <0.001).Similar study was done on Chines population with (p <0.05).30 Due to the above controversial results, we planned our study to find the association of ACE gene polymorphism with HTN in KPK Pakistani population which has not been studied yet. Here, ACE is linked to hypertensive disorder.