About 50 to 60% of patients are sensitive to salt due to genetics and there is chance to develop essential hypertension.6 It is estimated that 30-50% of hypertension is due to genetics and up to now only 2-3% of polymorphism has been found.7 Among various genes polymorphisms ACE gene have association with hypertension.8 Angiotensinogen is the precursor of angiotensin and its production occur in the liver. The gene discussed is ACE; the disease is essential hypertension.