Moreover, high levels of inflammatory factors such as TNF-ɑ and IL-6 have been associated with AIS development, probably due to the resulting increased adhesion of endothelial and white blood cells and accelerated thrombosis.18,19 According to Mechtouff L et al.20, the levels of TNF-ɑ were abnormally high in patients with AIS before treatment, but decreased significantly after it. This evidence concerns the gene IL6 and androgen insensitivity syndrome.