GSEA revealed that high TET2 expression in both AD and CRC was associated with enrichment in 10 pathways related to the inflammatory response and immune regulation, including the intestinal immune network for IgA production, antigen processing and presentation, Th1 and Th2 cell differentiation, cell adhesion molecules, Th/17 cell differentiation, NOD-like receptor signaling pathway, C-type lectin receptor signaling pathway, sphingolipid signaling pathway, apoptosis, and NF-kappa B signaling pathway. The gene discussed is TET2; the disease is colorectal carcinoma.