Particularly in colorectal cancer, NFIL3 expression exhibited a correlation with poorer prognosis, as evidenced by significant outcomes in overall survival (OS; total number = 177, HR = 1.9, Cox P = 0.017054), disease-free survival (DFS; total number = 145, HR = 2.7, Cox P = 0.009801), and disease-specific survival (DSS; total number = 177, HR = 1.87, Cox P = 0.044339) in GSE17536, as well as relapse-free survival (RFS; total number = 204, HR = 1.35, Cox P = 0.001549) in GSE12276 and OS (total number = 55, HR = 2.16, Cox P = 0.030166) in GSE17537 (Figure 3A-3E). The gene discussed is NFIL3; the disease is colorectal cancer.