Mechanism exploration: Although this study found that the increased expression of Lnc-CLSTN2-1:1 in osteosarcoma cells is associated with cell proliferation, invasion, and migration, as well as the mechanism of regulating antioxidant stress through the PI3K/AKT signaling pathway, the specific molecular mechanism has not been fully clarified. The gene discussed is AKT1; the disease is osteosarcoma.