Among these 10 signature genes, KLF2 could inhibit cell growth in a human CRC cell line 39, SCR2 was determined as a predictive biomarker and was associated with immunological cell infiltration in CRC 40, and CXCL13 was associated with poor survival in advanced CRC patients and may regulate 5-fluorouracil resistance 41, 42. This evidence concerns the gene KLF2 and colorectal carcinoma.