Nucleocytoplasmic trafficking pathways in particular are involved in several pathological conditions in cancer, in which the functions of key transporter proteins are counteracted or altered 33.Chromosome Region Maintenance 1 (CRM1), a nuclear transporter protein, mediates the export of approximately 220 proteins and mRNA across the nuclear envelope (NE) and is involved in the regulation of processes associated with cell proliferation, including cell cycle progression and apoptosis 34, 35. This evidence concerns the gene XPO1 and cancer.