For example, in the experimental lung metastasis of colon 26-M3.1 cancer or B16-BL6 melanoma cells, β-glucan derived from yeast significantly inhibited lung metastasis in a dose-dependent manner 42, and β-glucan from Lentinus edodes inhibits breast cancer progression and lung metastasis via the Nur77/HIF-1α axis 43. Here, HIF1A is linked to melanoma.