In a murine breast cancer model, Oghumu et al 19 confirmed that CXCR3 deficiency enhances tumor progression by promoting macrophage M2 polarization as well as that cyclooxygenase-2 (COX-2) inhibition blocks M2 macrophage differentiation and suppresses breast cancer metastasis. The gene discussed is CXCR3; the disease is breast carcinoma.