Furthermore, in a dose-dependent manner, Salmonella treatment led to a decrease in the phosphorylation of AKT, mTOR, and p70S6K, thereby indicating downregulation of the AKT/mTOR/p70S6K/β3-adrenoceptor pathway by Salmonella treatment in tumor cells (Fig. 3). The gene discussed is RPS6KB1; the disease is neoplasm.