A total of 31 tissue-gene pairs were observed for T2DM and GSD, including 16 genes (DMWD, GPN1, GTF3C2, IFT172, KRTCAP3, LINC01126, LINC01460, NRBP1, OASL, P2RX4, PPM1G, RBKS, SPPL3, SNX17, THADA, UNC119B), mainly expressed in multiple tissues from nervous and motor systems. Here, SPPL3 is linked to type 2 diabetes mellitus.