Alzheimer’s disease (n = 38), paired helical filaments (n = 34), tau protein (n = 31), neurofibrillary tangle (n = 27), pathology (n = 12), localization (n = 9), microtubule-associated protein (n = 8), identification (n = 7), progressive supranuclear palsy (n = 7), abnormal phosphorylation (n = 6), in vitro (n = 5). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.