The most-cited article, titled “Triple transgenic model of Alzheimer’s disease with plaques and tangles: Intracellular Aβ and synaptic dysfunction,” elucidates the pathogenesis of AD in mice, highlighting that Aβ deposits precede tau alterations and result in changes in long-term synaptic plasticity (Oddo et al., 2003). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.