MAPT and Cognitive impairment: From 1991 to 2018, extensive research covered diverse topics, including “protein tau,” “phosphorylation,” “Aβ,” “frontotemporal dementia,” “pathology,” “expression patterns,” “neurodegenerative diseases,” and “cognitive impairments.” Currently, the forefront of significant research involves “autophagy” and “genome-wide association (GWAS),” suggesting promising avenues for future scholarly investigations (Figure 7).