PINK1 is particularly prominent in mitochondrial autophagy, and mutations in PINK1 disrupt several parts of mitochondrial biology, resulting in mitochondrial dysfunction and leading to ineffective clearance of damaged mitochondria, which in turn triggers inflammation and the death of dopaminergic neurons, ultimately resulting in the development of PD (Ando et al., 2017). Here, PINK1 is linked to Parkinson disease.