NFKB1 and autoimmune disease: Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-kB has long been considered as a target for new anti-inflammatory drugs;98 however, these recent studies suggest this pathway may prove a difficult target in the treatment of chronic disease.96,98 Deregulated NF-κB activation contributes to the pathogenic processes of various inflammatory diseases.99