Intriguingly, PYY1–36 shares structural similarities with magainin 2, an antimicrobial peptide recognized for its protective function against bacterial and fungal infections in the skin of African clawed frogs.7,8 This structural resemblance has attracted further research into the potential inhibitory effect of PYY on the growth and viability of C. albicans, the predominant fungus residing in the human gut. Here, PYY is linked to fungal infectious disease.