Uniform manifold approximation and projection (UMAP) dimensionality reduction followed by FlowSOM metaclustering25,26 revealed that, besides γδ T cells and CD4+ effector memory T (TEM) cells, tumor-infiltrating Foxp3+ Treg cells also expressed IL-23R, representing a sizable fraction of total IL-23R-expressing T cells in the TME (Fig. 1e,f). This evidence concerns the gene IL23R and neoplasm.