Those tested could be split into four groups, depending on (1) the timing of the germline test with respect to the 2019 CRC diagnosis (pre- or post-diagnosis), and (2) the scope of the germline test (full screening of all MMR genes, versus targeted testing for a specific pathogenic variant in a member of a known LS family) (Table 2). This evidence concerns the gene LIAS and colorectal carcinoma.