CGAS and breast carcinoma: To determine whether an inflammatory response resulting from cGAS-STING signaling itself was sufficient to cause resistance to chemotherapy, we used a chemical mimic of the STING ligand, cyclic guanosine monophosphate-adenosine monophosphate (cGAMP), dimeric aminobenzimidazolec (diABZI) which functions as a STING agonist46 to activate the pathway in various breast cancer cell lines.