To corroborate SET-ZBTB11 complex-mediated modulation of cancer cell behaviors in vivo, we employed H1299-Luc2-tdT-2 reporter cells with stable knockdown of SET or ZBTB11 and monitored distal metastasis of the indicated cancer cells through a subcutaneous tumor xenograft mouse model (Fig. 4p). The gene discussed is SET; the disease is cancer.