ZBTB11 and cancer: Notably, the extent of ZBTB11 depletion by siRNA/shRNA in cancer cells was adequate to markedly reduce cell migration and invasion but not cell proliferation (Supplementary Figs. 4a and  5g–i), supporting the capability of ZBTB11-mediated metastatic regulation of cancer cells prior to or independent of ZBTB11-mediated changes in cell proliferation.