TF and cancer: Notably, the loci with ZBTB11 binding showed a significant enrichment around transcription starting sites (TSSs, range across −3 kb ~ +3 kb of TSS) genome wide with a consensus binding motif CC/AGGAAG (Fig. 2d, e), suggesting that ZBTB11 most likely functions as a transcription factor (TF) in terms of its regulation of gene expression in cancer cells.