TARDBP and amyotrophic lateral sclerosis: Even though only a small fraction of transcripts is changed in iNets with altered TDP-43 levels and in brains of patients with FTLD–ALS (Extended Data Fig. 9b and Supplementary Tables 7 and 8), our analysis shows that both overexpression and downregulation of TDP-43 recapitulate part of the transcriptomic alterations observed in affected neurons in patients with FTLD–ALS (Extended Data Fig. 9a,b and Supplementary Tables 7 and 8).