TARDBP and amyotrophic lateral sclerosis: Of note, expression of HA-tagged FUS, a protein that aggregates in the central nervous system (CNS) of patients with FTLD-FUS and ALS subtypes, induced weak NPTX2 accumulation in only a minority of transgenic iNet neurons (Extended Data Fig. 11a), confirming the specificity of NPTX2 upregulation to TDP-43 dysfunction.