To this end, we investigated autopsy brain material from 20 patients with neurodegenerative conditions, including 7 FTLD with TDP-43-immunoreactive pathology (FTLD-TDP), 1 ALS, 3 FTLD-FUS, 4 FTLD-tau and 5 Alzheimer’s disease. Here, TARDBP is linked to early-onset autosomal dominant Alzheimer disease.