However, the combination of losartan with chemoradiotherapy (FOLFIRINOX + CRT) after chemotherapy can significantly reduce the number of immunosuppressive Treg and FOXP3 + tumor cells in PDAC lesions, and increase anti-tumor CD8 + T cell infiltration, so as to positively reshape the immunosuppressive microenvironment16. Here, FOXP3 is linked to neoplasm.