CRHR2 and neoplasm: Through univariate Cox regression analysis, nine genes, including 3 oncogenes (HTR3C, CRHR2 and AGTR1), 6 tumor suppressor genes (CD8A, CD3E, SERPIND1, CXCR6, BMX and CD247) were proved to be correlated with the overall survival of EC patients (Fig. 3A).