Through univariate Cox regression analysis, nine genes, including 3 oncogenes (HTR3C, CRHR2 and AGTR1), 6 tumor suppressor genes (CD8A, CD3E, SERPIND1, CXCR6, BMX and CD247) were proved to be correlated with the overall survival of EC patients (Fig. 3A). This evidence concerns the gene CD8A and neoplasm.