We first performed a series of in vitro co-incubation experiments: Adding simvastatin at the previously established dose to our killing assays completely rescued the sensitivity of MOLM13-TP53−/− or MV4-11-TP53−/− AML cells co-incubated with CAR T-cells over several log2 fold E:T range with CD33- as well as CD123-targeting CAR T-cells (Figs. 5B,C and EV4E,F). The gene discussed is TP53; the disease is acute myeloid leukemia.