TP53 and acute myeloid leukemia: Among the most differentially expressed genes between CAR T-cells attacking MOLM13-TP53−/− AML cells, i.e., CART(MOLM13-TP53−/−) and CAR T-cells attacking MOLM13-TP53+/+ AML cells, i.e., CART(MOLM13-TP53+/+) we identified two known master regulators of T-cell fate and downstream effectors of the Wnt signaling pathway TCF7 (Transcription factor 7, also known as T-cell-specific transcription factor 1, TCF-1), and EOMES (Eomesodermin) (Fig. 4F).