As a first step, we analyzed the kinetics of the on-target activity of both drugs at the established concentrations for several days after washout: we observed sustained upregulation of LDLR over the course of 6 days after removal of simvastatin in both analyzed AML cell lines and genotypes (Figs. 6B and EV4D). The gene discussed is LDLR; the disease is acute myeloid leukemia.