TP53 and acute myeloid leukemia: We observed TP53-dependent differences in exhaustion profiles: CAR T-cells co-incubated with MOLM13-TP53−/− AML cells exhibited a more exhausted T-cell phenotype than CAR T-cells co-incubated with MOLM13-TP53+/+ AML cells as demonstrated by a higher percentage of CAR T-cells being double- or triple-positive for the above exhaustion markers (Fig. 2D,E; Appendix Fig. S2).