We validated our findings by measuring the expression of the canonical mevalonate pathway genes HMGCR and HMGCS1 via RT-qPCR in the setting of anti-CD33 as well as anti-CD123 CAR T-cell attack in isogenic MOLM13-TP53 and MV4-11-TP53 AML cell lines (Fig. EV3H). The gene discussed is HMGCS1; the disease is acute myeloid leukemia.