TP53 and acute myeloid leukemia: With regards to CAR T-cell-intrinsic resistance pathways, transcriptional profiling of CAR T-cells attacking TP53-deficient AML cells revealed a significant downregulation of the transcription factors TCF7 and EOMES, both of which are signaling downstream of the canonical Wnt pathway, and are essential in T-cell development, differentiation, and survival (Staal et al, 2004; Zhou et al, 2010).