TP53 and acute myeloid leukemia: Co-incubation of CAR T-cells with MOLM13-TP53+/+ and MOLM13-TP53−/− together in a competitive manner revealed the preferential killing of MOLM13-TP53+/+ over MOLM13-TP53−/− AML cells and continuous outgrowth of MOLM13-TP53−/− AML cells in the co-cultures, irrespective of E:T or initial MOLM13-TP53+/+/MOLM13-TP53−/− ratios (Fig. EV1D–G).