TP53 and acute myeloid leukemia: However, BIO-acetoxime pretreatment of both AML cells and CAR T-cells failed to rescue the specific killing rate of TP53-mutant MOLM13 or MV4-11 AML cells by CAR T-cells (Fig. 6A,D,E and EV5D)—consistent with above washout experiments, which showed rapid normalization of Wnt signaling upon drug removal (Figs. 6C and EV5C).