Two-way ANOVA analysis also showed APP levels were higher in TG-AD than WT rats independently of age and treatment [4-months Fig. 5C; F(1,19) = 71.91; p < 0.0001 for genotype; 11 months Fig. 5D, F(1,20) = 40.38; p < 0.0001 for genotype. The gene discussed is APP; the disease is Alzheimer disease.