Up-regulation of the APPsw (1.99 fold) and PS1-∆E9 (2.11 fold) genes in TGNT vs WTNT female rats was expected, because besides the endogenous genes, the TG-AD rats express human APPswe and PS1ΔE9 mutations driven by the prion promoter (Fig. 1B). This evidence concerns the gene PSEN1 and Alzheimer disease.