YAP1 and hepatocellular carcinoma: FZD10 activation in hepatocellular carcinoma CSCs was reported to be facilitated via METTL3-dependent m6A methylation; further, it was shown that FZD10 promotes self-renewal, tumorigenicity, and metastasis in hepatocellular carcinoma (HCC) CSCs via β-catenin and YAP1 activation, predicting a poor prognosis [29].