Conversely, inhibition of TLR4 reduces the expression of inflammatory mediators and improves cardiac function [56, 57].Surprisingly, in the present study, it was found that IFIT2, IFITM2, and OAS2, which were previously reported to be mainly involved in intrinsic cellular immune processes, are closely associated with HF. The gene discussed is IFITM2; the disease is hydrops fetalis.