The Cox proportional hazards model revealed that the factors associated with overall survival were presence of sarcopenia (HR 1.80, 95% CI 1.20–2.69, p = 0.004), AFP (HR 2.21, 95% CI 1.51–3.25, p < 0.001), DCP (HR 2.90, 95% CI 2.10–4.02, p < 0.001), Child–Pugh score 6 (HR 1.81, 95% CI 1.31–2.51, p < 0.001), NBNC group (HR 1.61, 95% CI 1.16–2.23, p = 0.004), ALBI grade 2 (HR 1.92, 95% CI 1.40–2.65, p < 0.001), Within up to 7 (HR 2.60, 95% CI 1.87–3.61, p < 0.001) and responder (HR 0.31, 95% CI 0.22–0.44, p < 0.001) in univariate analysis (Table 5). This evidence concerns the gene AFP and sarcopenia.