Besides BRCA1/2, many pathogenic/likely pathogenic (P/LP) variants in high and moderate penetrance genes for breast-ovarian cancer, including TP53, CDH1, PALB2, STK11, PTEN, CHEK2, ATM, BARD1, BRIP1, and RAD51D, were increasingly identified after the advent of next-generation sequencing (NGS)-based testing5–7. Here, BRCA1 is linked to Hereditary breast and ovarian cancer syndrome.