Importantly, CD48 overexpression significantly restored the sensitivity of KDM6A-KO MM cells to Dara-mediated ADCC (Fig. 6e and Supplementary Fig. 5g) and recovered IFN-γ production, secretion of perforin and granzyme B by NK cells (Fig. 6f-h). This evidence concerns the gene GZMB and Miyoshi myopathy.