Moreover, PZQ is reported to prevent the development of pulmonary arterial hypertension associated with S. mansoni infection [11] and reverse the changes of severe pulmonary vascular remodeling associated with perivascular inflammation by reducing mRNA levels of inflammatory cytokines IL-13, IL-8, and IL-4 in lungs [12]. This evidence concerns the gene CXCL8 and pulmonary arterial hypertension.