VEGFA and acute myeloid leukemia: We also profiled LSCs at the single cell level using single cell RNA-Seq (scRNA-Seq) which, together with perturbation experiments using a novel patient derived xenograft (PDX) model for t(8;21) AML, identified the growth factors VEGFA and IL-5 and their receptors as key factors aberrantly driving the growth of this specific LSC subtype.