Moreover, inspection of LSC and blast cell single cell data10 demonstrated that this type of AML also activates a specific, but different cytokine receptor, CSF2RB, the common subunit for the IL-5, IL-3 and GM-CSF receptors (Supplementary Fig. 8I, J) suggesting that ectopic pathway expression is used by LSCs in more than one AML sub-type. Here, IL5 is linked to acute myeloid leukemia.